By Alex Avdeef
Explains tips on how to practice and research the result of the newest physicochemical methods
With this ebook as their consultant, readers have entry to all of the present info had to completely examine and adequately ascertain a compound's pharmaceutical homes and their results on drug absorption. The e-book emphasizes oral absorption, explaining the entire physicochemical equipment used this day to research drug applicants. additionally, the writer presents professional suggestions to assist readers learn the result of their experiences on the way to choose the main promising drug candidates.
This Second Edition has been completely up-to-date and revised, incorporating the entire most up-to-date examine findings, equipment, and assets, including:
Descriptions and functions of recent PAMPA versions, drawing on greater than thirty papers released by means of the author's study group
Two new chapters interpreting permeability and Caco-2/MDCK and permeability and the blood-brain barrier
Expanded info and techniques to help pKa determination
New examples explaining the therapy of essentially insoluble attempt compounds
Additional case reports demonstrating using the newest physicochemical techniques
New, revised, and improved database tables through the book
Well over two hundred drawings aid readers larger comprehend tricky ideas and supply a visible consultant to complicated methods. additionally, over 800 references function a gateway to the first literature within the box, facilitating additional learn into the entire themes lined within the book.
This Second Edition is usually recommended as a reference for researchers in pharmaceutical R&D in addition to in agrochemical, environmental, and different similar components of analysis. it's also advised as a supplemental textual content for graduate classes in pharmaceutics.
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